N-Terminal Peptide Fragment Overview
TB-500 Thymosin Beta-4 Fragment 1-4 is a synthetic N-terminal tetrapeptide derived from thymosin β4, corresponding to the Ac-Ser-Asp-Lys-Pro sequence. This minimal fragment is supplied as a research-grade tool for focused in vitro studies examining sequence-specific biological activity.
Structural Focus & Functional Insight
As the isolated N-terminal domain of thymosin β4, TB1404 enables researchers to investigate structure–function relationships distinct from the full-length peptide. Laboratory models explore how this short sequence influences cytoskeletal behavior and intracellular signaling pathways.
Cellular & Molecular Research Applications
In controlled experimental settings, this fragment is utilized in studies of cell migration dynamics, angiogenic signaling, inflammatory modulation, and tissue repair–related mechanisms. Comparative research frequently contrasts TB1404 with intact thymosin β4 to identify minimal active regions and peptide–protein interaction profiles.
Stability & Laboratory Handling
Provided as a white to off-white lyophilized powder, TB1404 demonstrates reliable stability when stored under recommended conditions. It is readily soluble in water and physiological buffers, supporting consistent preparation for biochemical and cellular assays.
Pharmaceutical-Grade Manufacturing by SynoPept
Manufactured in the United States by SynoPept under GMP-compliant, pharmaceutical-grade standards, each batch undergoes independent third-party testing. Quality assurance includes verification of molecular identity, purity, sterility, and endotoxin limits to ensure reproducible research performance.
Analytical Specifications
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Sequence: Ac-Ser-Asp-Lys-Pro
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Molecular Formula: C20H33N5O9
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Molecular Weight: 487.5 g/mol
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CAS Number: 120081-14-3
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PubChem CID: 65938
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Synonyms: Ac-SDKP, N-acetyl-seryl-aspartyl-lysyl-proline, Goralatide, Seraspenide
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Purity: ≥98% (HPLC)
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Form: White to off-white lyophilized powder
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Solubility: Water and physiological buffers
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Storage: −20°C, tightly sealed, protected from light and moisture
Research-Only Designation
TB1404 is supplied exclusively for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
