Mitochondrial Peptide Overview
Humanin is a 24–amino acid mitochondrial-derived peptide encoded within the mitochondrial genome and widely studied for its role in cellular stress response mechanisms. This research-grade peptide serves as a precise tool for investigating mitochondrial signaling and cytoprotective pathways in controlled laboratory environments.
Cellular Stress & Survival Pathways
In experimental models, Humanin has been examined for its interaction with receptor-mediated signaling systems involved in apoptosis regulation. In vitro studies explore how this peptide influences programmed cell death pathways and cellular resilience under oxidative stress conditions.
Neurodegeneration & Metabolic Research
Laboratory research applications include investigations into neuronal survival, age-associated cellular degeneration, insulin sensitivity models, and retinal pigment epithelial cell viability. Humanin is frequently used to study the relationship between mitochondrial function and long-term cellular maintenance.
Structural Stability & Experimental Use
Supplied as a white lyophilized powder, HUMN24 demonstrates reliable stability when stored under recommended conditions. Its solubility profile supports consistent preparation for biochemical and cellular assays requiring high reproducibility.
Pharmaceutical-Grade Production
Manufactured in the United States under GMP-compliant, pharmaceutical-grade standards, each batch undergoes comprehensive third-party testing. Quality verification includes molecular identity confirmation, purity analysis, sterility, and endotoxin assessment.
Analytical Specifications
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Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
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Molecular Formula: C119H204N34O32S2
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Molecular Weight: 2687.28 g/mol
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CAS Number: 330936-69-1
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PubChem CID: 16131438
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Synonyms: HN, Mitochondrial-derived peptide
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Purity: ≥99% (HPLC)
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Form: White lyophilized powder
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Solubility: Sterile water or mildly acidic buffers
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Storage: −20°C, tightly sealed, protected from heat and moisture
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Shelf Life: 36 months under proper storage conditions
Research-Only Classification
HUMN24 is supplied exclusively for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
