Neuroendocrine Peptide Overview
Kisspeptin-10 is a synthetic decapeptide corresponding to amino acid residues 45–54 of the metastin hormone sequence. Identified from the KISS1 gene, this peptide is widely utilized in molecular and cellular research focused on reproductive and neuroendocrine regulation.
GPR54 Receptor Activation
In controlled laboratory models, Kisspeptin-10 functions as a potent agonist of the GPR54 (KISS1R) G protein–coupled receptor. Research applications investigate its role in gonadotropin-releasing hormone (GnRH) signaling cascades and downstream pituitary responses.
Endocrine & Cellular Research Applications
KP10RX is commonly applied in in vitro studies examining luteinizing hormone secretion, puberty-associated neuroendocrine pathways, and hypothalamic–pituitary axis regulation. Additional experimental models explore its involvement in cellular migration and metastasis suppression mechanisms.
High-Purity Manufacturing Standards
Manufactured in the United States under GMP-compliant, pharmaceutical-grade conditions, this peptide is produced with stringent process controls. Each batch is independently validated by certified third-party laboratories to confirm identity, purity, sterility, and endotoxin limits.
Chemical & Analytical Specifications
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Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
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Molecular Formula: C₆₃H₈₃N₁₇O₁₄
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Molecular Weight: 1302.45 g/mol
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CAS Number: 374675-21-5
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PubChem CID: 25240297
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Synonyms: Metastin (45–54), KP-10, Kisspeptin 10 (Human), KISS-1 (112–121)
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Purity: ≥99% (HPLC)
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Form: White lyophilized powder
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Solubility: Soluble in water or mildly acidic buffers
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Storage: −20°C, tightly sealed, protected from heat and moisture
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Shelf Life: 36 months under recommended storage conditions
Research Use Statement
KP10RX is supplied exclusively for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
