Product Description
PNC-27 Peptide Overview
PNC-27 is a synthetic 32-amino-acid chimeric peptide designed for advanced cancer biology research. The peptide consists of an HDM-2–binding domain derived from the p53 tumor suppressor protein (residues 12–26) fused to a cell-penetrating peptide (CPP) sequence from Antennapedia, enabling efficient cellular membrane interaction.
This membrane-active peptide selectively associates with HDM-2 proteins expressed on cancer cell membranes, where it promotes oligomeric pore formation and membrane destabilization through membranolytic mechanisms. PNC-27 is widely studied as a molecular tool for investigating selective cytotoxicity pathways distinct from classical apoptosis.
Research Applications
PNC-27 is intended exclusively for in vitro research use and has been utilized in controlled laboratory studies involving:
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HDM-2 / p53 protein interaction analysis
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Cancer cell membrane permeabilization mechanisms
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Oligomeric pore formation and membranolysis pathways
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Selective necrotic cell death mechanisms
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Anticancer peptide screening across multiple tumor cell lines
Published research models include breast, pancreatic, ovarian, leukemia, and melanoma cell systems.
Product Quality and Manufacturing
PNC-27 is supplied as a pharmaceutical-grade lyophilized powder and manufactured in the USA under GMP-compliant conditions. Each batch undergoes independent third-party analytical testing to verify molecular identity, purity, and consistency. Endotoxin and sterility controls are maintained to meet rigorous research standards.
SynoPept ensures reliable supply, verified documentation, and rapid fulfillment to support reproducible scientific investigation.
For in vitro research use only. Not intended for diagnostic, therapeutic, or clinical use.
