Functional Peptide Fragment Overview
TB-500 Fragment 17–23 is a synthetic heptapeptide segment of Thymosin Beta-4, representing the minimal sequence responsible for actin interaction. This research-grade fragment isolates the core functional domain, enabling focused in vitro studies on cytoskeletal regulation.
Actin Binding & Cytoskeletal Dynamics
The LKKTETQ sequence corresponds to the primary G-actin–binding motif of thymosin β4. Laboratory investigations utilize TB1723 to examine actin sequestration, inhibition of filament polymerization, and cytoskeletal remodeling under controlled experimental conditions.
Targeted Research Applications
By separating actin-binding activity from other TB4-associated functions, this fragment supports structure–activity relationship (SAR) studies, comparative peptide analysis, and minimal-domain functional mapping. Research areas include cell migration signaling, angiogenic pathway modeling, and tissue repair–related cellular responses.
Stability & Laboratory Handling
Supplied as a white to off-white lyophilized powder, TB1723 offers flexible handling for laboratory workflows. It reconstitutes readily in sterile or bacteriostatic water and remains stable when stored under recommended short- and long-term conditions.
Pharmaceutical-Grade Manufacturing by SynoPept
Manufactured in the United States by SynoPept under GMP-compliant, pharmaceutical-grade standards, each batch undergoes comprehensive third-party testing. Quality verification includes molecular identity, ≥99% purity confirmation, sterility, and endotoxin assessment to ensure reproducible research performance.
Analytical Specifications
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Sequence: Leu-Lys-Lys-Thr-Glu-Thr-Gln (LKKTETQ)
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Molecular Formula: C36H66N10O13
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Molecular Weight: 846.97 g/mol
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CAS Number: 476014-70-7
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PubChem CID: 10169788
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Synonyms: Thymosin Beta-4 (17–23), Fequesetide, Ac-LKKTETQ
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Purity: ≥99% (HPLC)
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Form: White to off-white lyophilized powder
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Solubility: Water and physiological buffers
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Storage: ≤6°C short term; −20°C long term, protected from light and moisture
Research-Only Designation
TB1723 is supplied exclusively for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
