Mitochondrial Peptide Blend Overview
MOTSHN is a research-grade peptide blend combining MOTS-c (16 amino acids) and Humanin (24 amino acids), both encoded within the mitochondrial genome. This combination provides a versatile tool for studying mitochondrial signaling, cellular metabolism, and stress response pathways in laboratory models.
Functional Research Applications
MOTS-c modulates AMPK-mediated metabolic pathways affecting glucose uptake and energy homeostasis, while Humanin regulates oxidative stress response and apoptosis-related pathways. Together, this blend enables investigations into mitochondrial cross-talk, insulin sensitivity, and cellular longevity mechanisms.
Stability and Handling
Supplied as white lyophilized powders, both peptides maintain stability when stored at −20°C and reconstitute readily in sterile water. Humanin is additionally soluble in slightly acidic buffers. The blend ensures reproducible performance in cellular, biochemical, and metabolic assays.
Quality Assurance & Manufacturing
Produced in the USA under GMP-compliant, pharmaceutical-grade conditions, MOTSHN is independently verified for identity, purity, sterility, and endotoxin limits by certified third-party laboratories. Each batch meets stringent quality standards suitable for high-precision research.
Technical Specifications
| Specification | MOTS-c | Humanin |
|---|---|---|
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| Molecular Formula | C101H152N28O22S2 | C119H204N34O32S2 |
| Molecular Weight | 2174.6 g/mol | 2687.28 g/mol |
| CAS Number | 1627580-64-6 | 330936-69-1 |
| PubChem CID | 255386757 | 16131438 |
| Purity | ≥99% (HPLC) | ≥99% (HPLC) |
| Solubility | Sterile water | Sterile water or slightly acidic buffers |
| Form | White lyophilized powder | White lyophilized powder |
| Storage | −20°C, sealed, protected from heat | −20°C, sealed, protected from heat |
| Shelf Life | 36 months | 36 months |
Research Use Statement
MOTSHN is supplied exclusively for in vitro research use only (RUO) and is not intended for human or veterinary consumption, diagnostic use, or therapeutic application.
