Melanocortin Research Peptide
Setmelanotide is a cyclic octapeptide developed for advanced investigation of the melanocortin-4 receptor (MC4R) signaling system. Its constrained cyclic structure supports receptor-selective studies within controlled in vitro experimental environments.
MC4R Signaling & Pathway Focus
In laboratory models, SETMEL is utilized to examine high-affinity MC4R binding and downstream intracellular signaling events. Research applications include analysis of melanocortin-mediated transcriptional activity, hypothalamic circuit signaling, and leptin–melanocortin pathway dynamics.
Metabolic Mechanism Investigation
Research protocols employ Setmelanotide to study energy homeostasis mechanisms, POMC neuron signaling behavior, and appetite-regulating molecular pathways. Its stability profile enables consistent performance in extended cellular and biochemical assays.
Structural Stability & Performance
The peptide’s cyclic configuration enhances resistance to degradation during experimental workflows. SETMEL is supplied as a white to off-white lyophilized powder and demonstrates reliable solubility in DMSO for laboratory preparation.
Pharmaceutical-Grade Manufacturing
Manufactured in the United States under GMP-compliant, pharmaceutical-grade standards, each batch undergoes independent third-party verification. Quality testing confirms identity, purity, sterility, and endotoxin compliance to support reproducible research outcomes.
Analytical Specifications
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Sequence: Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH₂
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Molecular Formula: C49H68N18O9S2
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Molecular Weight: 1117.31 g/mol
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CAS Number: 920014-72-8
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PubChem CID: 11993702
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Synonyms: RM-493, BIM-22493, IRC-022493
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Purity: ≥98.5% (HPLC)
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Form: White to off-white lyophilized powder
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Solubility: DMSO
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Storage: −20°C, tightly sealed, protected from light and moisture
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Shelf Life: >2 years under recommended storage conditions
Research-Only Designation
SETMEL is supplied strictly for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
