Mitochondrial Peptide Overview
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA open reading frame. This research-grade compound is employed in laboratory studies to investigate mitochondrial signaling, metabolic regulation, and cellular energy homeostasis.
Mechanistic Research Applications
MOTS-c modulates AMPK-mediated metabolic pathways, influencing glucose uptake in skeletal muscle cells and overall cellular energy balance. Laboratory investigations include insulin resistance models, osteoblast function, and mitochondrial-related longevity research.
Stability and Handling
Supplied as a white lyophilized powder, MOTSC is stable under recommended storage conditions (≤−18°C) and reconstitutes easily in sterile water for short-term experimental use. Its formulation supports reproducible results in biochemical and cellular assays.
Quality-Controlled Manufacturing
Manufactured in the United States under GMP-compliant, pharmaceutical-grade standards, each batch undergoes rigorous third-party testing to confirm identity, purity, sterility, and endotoxin levels, ensuring consistent laboratory performance.
Technical Specifications
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Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
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Molecular Formula: C101H152N28O22S2
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Molecular Weight: 2174.6 g/mol
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CAS Number: 1627580-64-6
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PubChem CID: 255386757
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Synonyms: 12S rRF-encoded mitochondrial peptide
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Purity: ≥98% (HPLC)
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Solubility: Sterile water
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Form: White lyophilized powder
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Storage: ≤−18°C (lyophilized), 2–8°C short-term after reconstitution
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Shelf Life: 36 months under proper storage conditions
Research-Only Designation
MOTSC is intended exclusively for in vitro research use (RUO). It is not approved for human or animal consumption, diagnostic procedures, or therapeutic application.
