GHRH Fragment Overview
Sermorelin is a synthetic 29–amino acid GHRH (1–29) analog, representing the biologically active N-terminal segment of native growth hormone–releasing hormone. This research-grade peptide is designed for precise in vitro studies of endocrine signaling.
Receptor Binding & Signal Dynamics
In laboratory models, SER29 is utilized to examine GHRH receptor (GHRHR) interactions, receptor affinity, and downstream signal transduction. Experimental protocols explore pulsatile growth hormone signaling patterns and somatotroph cell responses under controlled conditions.
Neuroendocrine Pathway Research
Researchers apply Sermorelin to study feedback regulation involving somatostatin, interactions within the IGF-1 axis, and broader neuroendocrine cascade mechanisms. Its defined sequence supports reproducible investigations into physiological GH regulation frameworks.
Pharmaceutical-Grade Manufacturing
Manufactured in the United States under GMP-compliant, pharmaceutical-grade standards, SER29 undergoes comprehensive third-party testing. Quality control includes identity confirmation, purity analysis, sterility, and endotoxin screening to meet rigorous research requirements.
Analytical Specifications
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Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
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Molecular Formula: C149H246N44O42S
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Molecular Weight: 3357.93 g/mol
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CAS Number: 86168-78-7 (free base); 114466-38-5 (acetate)
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PubChem CID: 16132413
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Synonyms: GHRH (1–29), GRF (1–29), Growth Hormone–Releasing Factor, Geref
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Purity: ≥98.5% (HPLC)
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Form: White lyophilized powder
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Solubility: Reconstitutable in bacteriostatic water or sterile saline (pH 5.0–5.5)
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Storage: Lyophilized at 2–8°C, protected from light; reconstituted solution refrigerated
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Shelf Life: 36 months (lyophilized); 28–90 days post-reconstitution
Research-Only Classification
SER29 is supplied strictly for in vitro research use only (RUO). It is not intended for human or animal consumption, diagnostic use, or therapeutic application.
